Tapentadol is partially metabolized through the hepatic enzymes CYP2C9, CYP2C19, and CYP2D6 so it innately has interactions with prescription drugs that greatly enhance or repress the action/expression of one or more of these enzymes, together with with substrates of those enzymes (resulting from competition to the enzyme); some enzyme mediators/substrates https://davidr009itc1.empirewiki.com/user