Chemotherapy was potentiated by E7449 and single agent had considerable antitumor action in BRCA-deficient xenografts. Moreover, E7449 inhibited Wnt/β-catenin signaling in colon cancer cell traces, probable by means of TNKS inhibition. Per this probability, E7449 stabilized axin and TNKS proteins leading to β-catenin de-stabilization and drastically altered expression of Wnt https://jeanw688isa2.mysticwiki.com/user