Metabolic alterations connected to T2D are well characterised by epidemiological and research centered scientific studies. The pathogenesis and progression of T2D is ascribed to four mechanisms; improved advanced glycation stop product or service (AGE) development, increased polyol pathway flux, activation of protein kinase C (PKC) isoforms, and amplified hexosamine pathway https://www.directivepublications.org/journal-of-diabetology-research/