In older sufferers, this is vital to comprehend as polypharmacy is widespread and can potentiate the chance of DDIs and ADRs. Hence, concurrent ingestion of CYP2D6 inhibitors or inducers could potentiate or block tramadol conversion into ODT and This may enhance or lessen efficacy/ADRs of the prescribed tramadol. Literature https://hemalchem.com/product/o-dsmt/